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Article

Positional mapping of PRKD1, NRP1 and PRDM1 as novel candidate disease genes in truncus arteriosus.

Journal of medical genetics - 1 May 2015

Shaheen Ranad, Al Hashem Amal, Alghamdi Mohammed H, Seidahmad Mohammed Zain, Wakil Salma M, Dagriri Khalid, Keavney Bernard, Goodship Judith, Alyousif Saad, Al-Habshan Fahad M, Alhussein Khalid, Almoisheer Agaadir, Ibrahim Niema, Alkuraya Fowzan S

Abstract excerpt

BACKGROUND: Truncus arteriosus (TA) is characterised by failure of septation of the outflow tract into aortic and pulmonary trunks and is associated with high morbidity and mortality. Although ranked among the least common congenital heart defects, TA provides an excellent model for the role of i...

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Source

Identifiers

PMID: 25713110
DOI: 10.1136/jmedgenet-2015-102992

Genes

NRP1
PRDM1
PRKD1
TBX1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25713110-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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