Article
The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats.
Neuroscience letters - 30 Mar 2015
Ding Xin, Sun Bin, Huang Jian, Xu Lixiao, Pan Jian, Fang Chen, Tao Yanfang, Hu Shukun, Li Ronghu, Han Xing, Miao Po, Wang Ying, Yu Jian, Feng Xing
Abstract excerpt
Circadian rhythm disorder is a common neurological deficit caused by neonatal hypoxic-ischemic brain damage (HIBD). However, little is known about its underlying mechanisms. Our previous studies revealed a significant elevation of clock genes at the protein, but not mRNA, levels in the pineal gland after neonatal HIBD. To investigate the mechanisms of post-transcriptional regulation on clock genes, we screened...
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