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Article

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer.

Oncotarget - 20 Feb 2015

Choe Min Ho, Min Joong Won, Jeon Hong Bae, Cho Dong-Hyung, Oh Jeong Su, Lee Hyun Gyu, Hwang Sang-Gu, An Sungkwan, Han Young-Hoon, Kim Jae-Sung

Abstract excerpt

Although targeting radioresistant tumor cells is essential for enhancing the efficacy of radiotherapy, the signals activated in resistant tumors are still unclear. This study shows that ERp57 contributes to radioresistance of laryngeal cancer by activating STAT3. Increased ERp57 was associated with the radioresistant phenotype of laryngeal cancer cells. Interestingly, increased interaction between ERp57 and STAT3...

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Share to Gene Expression Regulation, Enzymologic
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laryngeal Neoplasms

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Protein Disulfide-Isomerases

Share to Radiation Tolerance

Share to Squamous Cell Carcinoma of Head and Neck

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25605256
DOI: 10.18632/oncotarget.3042
PMCID: PMC4413608

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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