Article
Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features.
Genes, brain, and behavior - 1 Feb 2015
Ross J L, Tartaglia N, Merry D E, Dalva M, Zinn A R
Abstract excerpt
The male sex chromosome disorder, 47,XYY syndrome (XYY), is associated with increased risk for social-emotional difficulties, attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). We hypothesize that increased Y chromosome gene copy number in XYY leads to overexpression of Y-linked genes related to brain development and function, thereby increasing risk for these phenotypes. We...
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