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Article

Posterior cortical atrophy as an extreme phenotype of GRN mutations.

JAMA neurology - 1 Feb 2015

Caroppo Paola, Belin Catherine, Grabli David, Maillet Didier, De Septenville Anne, Migliaccio Raffaella, Clot Fabienne, Lamari Foudil, Camuzat Agnès, Brice Alexis, Dubois Bruno, Le Ber Isabelle

Abstract excerpt

IMPORTANCE: Posterior cortical atrophy (PCA) is characterized by progressive visuoperceptual and visuospatial deficits and commonly considered to be an atypical variant of Alzheimer disease. Mutations of the GRN gene are responsible for a large phenotypic spectrum, but, to our knowledge, the asso...

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Source

Identifiers

PMID: 25546130
DOI: 10.1001/jamaneurol.2014.3308

Genes

GRN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25546130-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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