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Article

Pseudo-fovea formation after gene therapy for RPE65-LCA.

Investigative ophthalmology & visual science - 23 Dec 2014

Cideciyan Artur V, Aguirre Geoffrey K, Jacobson Samuel G, Butt Omar H, Schwartz Sharon B, Swider Malgorzata, Roman Alejandro J, Sadigh Sam, Hauswirth William W

Abstract excerpt

PURPOSE: The purpose of this study was to evaluate fixation location and oculomotor characteristics of 15 patients with Leber congenital amaurosis (LCA) caused by RPE65 mutations (RPE65-LCA) who underwent retinal gene therapy. METHODS: Eye movements were quantified under infrared imaging of the retina while the subject fixated on a stationary target. In a subset of patients, letter recognition under retinal...

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Identifiers

PMID: 25537204
DOI: 10.1167/iovs.14-15895
PMCID: PMC4303042

Genes

RPE65

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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