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Article

Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes

8 Jan 2015

Abstract excerpt

BACKGROUND: Anesthetic cardioprotection reduces myocardial infarct size after ischemia-reperfusion injury. Currently, the role of microRNA in this process remains unknown. MicroRNAs are short, noncoding nucleotide sequences that negatively regulate gene expression through degradation or suppression of messenger RNA. In this study, the authors uncovered the functional role of microRNA-21 (miR-21) up-regulation...

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PMID: 25536091
DOI: 10.1097/aln.0000000000000567

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