Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DARS-associated leukoencephalopathy can mimic a steroid-responsive neuroinflammatory disorder.

Neurology - 20 Jan 2015

Wolf Nicole I, Toro Camilo, Kister Ilya, Latif Kartikasalwah Abd, Leventer Richard, Pizzino Amy, Simons Cas, Abbink Truus E M, Taft Ryan J, van der Knaap Marjo S, Vanderver Adeline

Abstract excerpt

OBJECTIVE: To describe the expanding clinical spectrum of a recently described hereditary leukoencephalopathy, hypomyelination with brainstem and spinal cord involvement and leg spasticity, which is caused by mutations in the aspartyl tRNA-synthetase encoding gene DARS, including patients with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartate-tRNA Ligase
Share to Cerebral Cortex
Share to Encephalitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lactic Acid

Share to Leukoencephalopathies

Share to Muscle Spasticity

Share to Spinal Cord

Share to Steroids

Source

Open in PubMed Open full text

Identifiers

PMID: 25527264
DOI: 10.1212/WNL.0000000000001157
PMCID: PMC4335995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25527264-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DARS-associated leukoencephalopathy can mimic a steroid-responsive neuroinflammatory disorder.PMID 25527264Read ↗

Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity.Semantic proximity Read ↗

Neuropathology of leukoencephalopathy with brainstem and spinal cord involvement and high lactate caused by a homozygous mutation of DARS2.Semantic proximity Read ↗

Leukoencephalopathy with brainstem and spinal cord involvement and normal lactate: a new mutation in the DARS2 gene.Semantic proximity Read ↗

Leukoencephalopathy with brain stem and spinal cord involvement and high lactate: a genetically proven case with distinct MRI findings.Semantic proximity Read ↗

Leukoencephalopathy with brainstem and spinal cord involvement caused by a novel mutation in the DARS2 gene.Semantic proximity Read ↗

Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Presenting Primarily with Exercise Intolerance: A Case Report.Semantic proximity Read ↗

Pearls & Oy-sters: CSF1R-Related Leukoencephalopathy With Spinal Cord Lesions Mimicking Multiple Sclerosis.Semantic proximity Read ↗

<i>DARS2</i> mutations in mitochondrial leucoencephalopathy and multiple sclerosisSemantic proximity Read ↗

[DARS mutations responsible for hypomyelination with brain stem and spinal cord involvement and leg spasticity: report of two cases and review of literature].Semantic proximity Read ↗

Leukoencephalopathia, demyelinating peripheral neuropathy and dural ectasia explained by a not formerly described de novo mutation in the SAMD9L gene, ends 27 years of investigations – A case reportSemantic proximity Read ↗

Early-onset leukoencephalopathy due to a homozygous missense mutation in the DARS2 gene.Semantic proximity Read ↗

Early-onset LBSL: how severe does it get?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.