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Article

The role of melanin pigment in melanoma

13 Dec 2014

Abstract excerpt

The synthesis of melanin, a multistep and highly regulated pathway, represents a major differentiated function of normal and malignant melanocytes (reviewed in Refs 1, 2). Although the main function of melanin is to protect against UV-induced damage, melanin pigment can also regulate epidermal homeostasis and thus can affect melanoma behaviour 3-7. Recently, Sarna et al. 8 started to test a hypothesis that...

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PMID: 25496715
DOI: 10.1111/exd.12618

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