Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.

Human reproduction (Oxford, England) - 1 Jan 2015

Aghajanova L, Mahadevan S, Altmäe S, Stavreus-Evers A, Regan L, Sebire N, Dixon P, Fisher R A, Van den Veyver I B

Abstract excerpt

STUDY QUESTION: Are mutations in NLRP2/7 (NACHT, LRR and PYD domains-containing protein 2/7) or KHDC3L (KH Domain Containing 3 Like) associated with recurrent pregnancy loss (RPL) or infertility? SUMMARY ANSWER: We found no evidence for mutations in NLRP2/7 or KHDC3L in unexplained RPL or infertility. WHAT IS KNOWN ALREADY: Mutations in NLRP7 and KHDC3L are known to cause biparental hydatidiform moles (BiHMs), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abortion, Habitual
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis Regulatory Proteins

Share to Cohort Studies

Share to DNA Mutational Analysis

Share to Infertility, Female

Share to Pregnancy

Share to Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25376457
DOI: 10.1093/humrep/deu296
PMCID: PMC4262469

Genes

NLRP2
NLRP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.PMID 25376457Read ↗

A recurrent intragenic genomic duplication, other novel mutations in NLRP7 and imprinting defects in recurrent biparental hydatidiform moles.Semantic proximity Read ↗

NLRP7 or KHDC3L genes and the etiology of molar pregnancies and recurrent miscarriage.Semantic proximity Read ↗

No evidence for mutations in NLRP7 and KHDC3L in women with androgenetic hydatidiform moles.Semantic proximity Read ↗

Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure.Semantic proximity Read ↗

Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform moleSemantic proximity Read ↗

KH domain containing 3 like (KHDC3L) frame-shift mutation causes both recurrent pregnancy loss and hydatidiform mole.Semantic proximity Read ↗

Biallelic NLRP7 variants in patients with recurrent hydatidiform mole: A review and expert consensus.Semantic proximity Read ↗

Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage.Semantic proximity Read ↗

Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region.Semantic proximity Read ↗

Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations.Semantic proximity Read ↗

Mutations in NLRP7 are associated with diploid biparental hydatidiform moles, but not androgenetic complete moles.Semantic proximity Read ↗

Novel NLRP7 mutations in familial recurrent hydatidiform mole: are NLRP7 mutations a risk for recurrent reproductive wastage?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.