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Article

Facioscapulohumeral Muscular Dystrophy As a Model for Epigenetic Regulation and Disease

22 Oct 2014

Abstract excerpt

SIGNIFICANCE: Aberrant epigenetic regulation is an integral aspect of many diseases and complex disorders. Facioscapulohumeral muscular dystrophy (FSHD), a progressive myopathy that afflicts individuals of all ages, is caused by disrupted genetic and epigenetic regulation of a macrosatellite repeat. FSHD provides a powerful model to investigate disease-relevant epigenetic modifiers and general mechanisms of...

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PMID: 25336259
DOI: 10.1089/ars.2014.6090

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