Article
Sequencing of the DKK1 gene in patients with anorectal malformations and hypospadias.
European journal of pediatrics - 1 May 2015
van de Putte Romy, Wijers Charlotte H W, de Blaauw Ivo, Feitz Wout F J, Marcelis Carlo L M, Hakobjan Marina, Sloots Cornelius E J, van Bever Yolande, Brunner Han G, Roeleveld Nel, van Rooij Iris A L M, van der Zanden Loes F M
Abstract excerpt
UNLABELLED: Anorectal malformations (ARM) are rare congenital malformations of the gastrointestinal tract. Approximately 60% of the patients have additional congenital malformations, such as hypospadias. A recently published article showed that deletion of one single gene, dickkopf WNT signaling pathway inhibitor-1 (Dkk1), resulted in an imperforate anus with rectourinary fistula and preputial hypospadias in...
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