Age-associated telomere attrition of lymphocytes<i>in vivo</i>is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

Abstract excerpt

Telomeres are essential in maintaining chromosome integrity and in controlling cellular replication. Attrition of telomere length in peripheral blood mononuclear cells (PBMCs) with age is well documented from cross-sectional studies. But the actual in vivo changes in telomere lengths and its relationship with the contributing factors within the individuals with age have not been fully addressed. In the present...

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