Molecular analysis of abnormal hemoglobins in beta chain in Aegean region of Turkey and first reports of hemoglobin Andrew-Minneapolis and Hb Hinsdale from Turkey.

doi:10.1179/1607845414Y.0000000193

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Article

Molecular analysis of abnormal hemoglobins in beta chain in Aegean region of Turkey and first reports of hemoglobin Andrew-Minneapolis and Hb Hinsdale from Turkey.

Hematology (Amsterdam, Netherlands) - 1 Jul 2015

Aykut Ayça, Onay Hüseyin, Durmaz Asude, Karaca Emin, Vergin Canan, Aydınok Yeşim, Özkınay Ferda

Abstract excerpt

OBJECTIVES: The Agean is one of the regions in Turkey where thalassemias and abnormal hemoglobins (Hbs) are prevalent. Combined heterozygosity of thalassemia mutations with a variety of structural Hb variants lead to an extremely wide spectrum of clinical and hematological phenotypes which is of importance for prenatal diagnosis. METHODS: One hundred and seventeen patients and carriers diagnosed by hemoglobin...

Topics

Female
Genotype
Hemoglobinopathies
Hemoglobins, Abnormal
Humans
Male
Mutation
Turkey

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Open in PubMed

Identifiers

PMID: 25313792
DOI: 10.1179/1607845414Y.0000000193

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