Article
Genotype-dependent variability in residual cone structure in achromatopsia: toward developing metrics for assessing cone health.
Investigative ophthalmology & visual science - 2 Oct 2014
Dubis Adam M, Cooper Robert F, Aboshiha Jonathan, Langlo Christopher S, Sundaram Venki, Liu Benjamin, Collison Frederick, Fishman Gerald A, Moore Anthony T, Webster Andrew R, Dubra Alfredo, Carroll Joseph, Michaelides Michel
Abstract excerpt
PURPOSE: Gene therapy trials for inherited photoreceptor disorders are planned. Anatomical metrics to select the best candidates and outcomes are needed. Adaptive optics (AO) imaging enables visualization of photoreceptor structure, although analytical tools are lacking. Here we present criteria to assess residual photoreceptor integrity in achromatopsia (ACHM). METHODS: Two AOSLOs, at the Medical College of...
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