Article
OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway.
Molecular cancer - 19 Sept 2014
Lu Ya-Ching, Chang Joseph T, Liao Chun-Ta, Kang Chung-Jan, Huang Shiang-Fu, Chen I-How, Huang Chi-Che, Huang Yu-Chen, Chen Wen-Ho, Tsai Chi-Ying, Wang Hung-Ming, Yen Tzu-Chen, You Guo-Rung, Chiang Chang-Hsu, Cheng Ann-Joy
Abstract excerpt
BACKGROUND: MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been addressed. METHODS: Cellular functions in response to miR-196 modulation were examined, including cell growth, migration, invasion and radio/chemosensitivity. Algorithm-based studies were used to...
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