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Article

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2014

Katayama Ryohei, Friboulet Luc, Koike Sumie, Lockerman Elizabeth L, Khan Tahsin M, Gainor Justin F, Iafrate A John, Takeuchi Kengo, Taiji Makoto, Okuno Yasushi, Fujita Naoya, Engelman Jeffrey A, Shaw Alice T

Abstract excerpt

PURPOSE: The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard therapy for patients with ALK-rearranged non-small cell lung cancer (NSCLC). Several next-generation ALK-TKIs have entered the clinic and have shown promising activity in crizotinib-resistant patients. As patients still relapse even on these next-generation ALK-TKIs, we examined mechanisms of resistance to the...

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Identifiers

PMID: 25228534
DOI: 10.1158/1078-0432.CCR-14-1511
PMCID: PMC4233168

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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