Article
Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.
Oncology research - 1 Jan 2013
Funakoshi Yohei, Mukohara Toru, Ekyalongo Roudy Chiminch, Tomioka Hideo, Kataoka Yu, Shimono Yohei, Chayahara Naoko, Toyoda Masanori, Kiyota Naomi, Fujiwara Yutaka, Minami Hironobu
Abstract excerpt
We previously established acquired resistant models for MET-tyrosine kinase inhibitors (TKIs) by continuously exposing the MET-amplified gastric cancer cell line MKN45 to MET-TKIs, PHA665752 (MKN45-PR), or GSK1363089 (MKN45-GR). We found resistant mechanisms caused by increased copy number of MET in both lines and Y1230H mutation in MKN45-PR. We also found that excessive MET signaling caused by these MET...
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