Different molecular levels of post-induction minimal residual disease may predict hematopoietic stem cell transplantation outcome in adult Philadelphia-negative acute lymphoblastic leukemia

Abstract excerpt

Minimal residual disease (MRD) is a powerful indicator of the risk of relapse in adult acute lymphoblastic leukemia (ALL), 1 used for the risk-oriented application of allogeneic stem cell transplantation (allo-SCT) in patients who remain MRD-positive (MRD+) following induction and consolidation chemotherapy. 2 , 3 , 4 Although allo-SCT is less effective in MRD+ state, 5 , 6 , 7 correlations between post-induction...

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