Article
[Treatment of two chronic myeloid leukemia patients with V299L mutation by using nilotinib].
Zhongguo shi yan xue ye xue za zhi - 1 Jun 2014
Yang Xiang-Chou, Qiu Hong-Xia, Zhang Su-Jiang, Wang Ju-Juan, Ouyang Yuan, Pan Liang-Qin, Qiao Chun, Li Jian-Yong
Abstract excerpt
This study was aimed to enhance clinical understanding the effect of nilotinib on CML patients with V299L mutation who were resistant to imatinib. Bone marrow specimens from 2 cases of CML with V299L mutation were collected before and after the treatment with nilotinib. ABL mutation was detected by nested reverse transcription polymerase chain reaction (PCR) followed by direct sequencing. The clinical...
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