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Population and genomic lessons from genetic analysis of two Indian populations.

Human genetics - 1 Oct 2014

Juyal Garima, Mondal Mayukh, Luisi Pierre, Laayouni Hafid, Sood Ajit, Midha Vandana, Heutink Peter, Bertranpetit Jaume, Thelma B K, Casals Ferran

Abstract excerpt

Indian demographic history includes special features such as founder effects, interpopulation segregation, complex social structure with a caste system and elevated frequency of consanguineous marriages. It also presents a higher frequency for some rare mendelian disorders and in the last two decades increased prevalence of some complex disorders. Despite the fact that India represents about one-sixth of the...

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PMID: 24980708
DOI: 10.1007/s00439-014-1462-0

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