Article
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.
Blood - 14 Aug 2014
Taur Ying, Jenq Robert R, Perales Miguel-Angel, Littmann Eric R, Morjaria Sejal, Ling Lilan, No Daniel, Gobourne Asia, Viale Agnes, Dahi Parastoo B, Ponce Doris M, Barker Juliet N, Giralt Sergio, van den Brink Marcel, Pamer Eric G
Abstract excerpt
Highly diverse bacterial populations inhabit the gastrointestinal tract and modulate host inflammation and promote immune tolerance. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the gastrointestinal mucosa is damaged, and colonizing bacteria are impacted, leading to an impaired intestinal microbiota with reduced diversity. We examined the impact of intestinal diversity on subsequent...
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