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Article

Targeted therapy resistance mechanisms and therapeutic implications in melanoma.

Hematology/oncology clinics of North America - 1 Jun 2014

Chen Guo, Davies Michael A

Abstract excerpt

Although selective mutant BRAF inhibitors have revolutionized the treatment of metastatic melanoma, the magnitude and duration of their clinical benefit are significantly undermined by de novo and acquired resistance. Functional studies, molecular characterization of clinical samples, and clinica...

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Topics

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Share to Drug Resistance, Neoplasm
Share to Melanoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 24880945
DOI: 10.1016/j.hoc.2014.03.001

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24880945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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