Article
Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection.
The Journal of experimental medicine - 2 Jun 2014
Liu Zhuoming, Reba Scott, Chen Wei-Dong, Porwal Suheel Kumar, Boom W Henry, Petersen Robert B, Rojas Roxana, Viswanathan Rajesh, Devireddy L
Abstract excerpt
Competition for iron influences host-pathogen interactions. Pathogens secrete small iron-binding moieties, siderophores, to acquire host iron. In response, the host secretes siderophore-binding proteins, such as lipocalin 24p3, which limit siderophore-mediated iron import into bacteria. Mammals produce 2,5-dihydroxy benzoic acid, a compound that resembles a bacterial siderophore. Our data suggest that bacteria...
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