Practitioner review: A critical perspective on gene-environment interaction models--what impact should they have on clinical perceptions and practice?

Abstract excerpt

BACKGROUND: Psychiatric disorders run in families, and early twin, family and adoption studies confirmed that this was due in part to shared genetic inheritance. While candidate gene studies largely failed to reliably identify genetic variants associated with psychiatric disorders, genome-wide association studies are beginning to do so. However, the proportion of phenotypic variance explained remains well below...

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