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Article

Conserved Oncogenic Behavior of the FAM83 Family Regulates MAPK Signaling in Human Cancer

15 Apr 2014

Abstract excerpt

UNLABELLED: FAM83B (family with sequence similarity 83, member B) was recently identified as a novel oncogene involved in activating CRAF/MAPK signaling and driving epithelial cell transformation. FAM83B is one of eight members of a protein family (FAM83) characterized by a highly conserved domain of unknown function (DUF1669), which is necessary and sufficient to drive transformation. Here, it is demonstrated...

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PMID: 24736947
DOI: 10.1158/1541-7786.mcr-13-0289

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