Article
The dopaminergic reward system and leisure time exercise behavior: a candidate allele study.
BioMed research international - 1 Jan 2014
Huppertz Charlotte, Bartels Meike, Groen-Blokhuis Maria M, Dolan Conor V, de Moor Marleen H M, Abdellaoui Abdel, van Beijsterveldt Catharina E M, Ehli Erik A, Hottenga Jouke-Jan, Willemsen Gonneke, Xiao Xiangjun, Scheet Paul, Davies Gareth E, Boomsma Dorret I, Hudziak James J, de Geus Eco J C
Abstract excerpt
PURPOSE: Twin studies provide evidence that genetic influences contribute strongly to individual differences in exercise behavior. We hypothesize that part of this heritability is explained by genetic variation in the dopaminergic reward system. Eight single nucleotide polymorphisms (SNPs in DRD1: rs265981, DRD2: rs6275, rs1800497, DRD3: rs6280, DRD4: rs1800955, DBH: , , and in COMT: ) and...