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Article

Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2014

Patoine Alexa, Gaumond Marie-Hélène, Jaiswal Prashant K, Fassier François, Rauch Frank, Moffatt Pierre

Abstract excerpt

BRIL/IFITM5 is a membrane protein present almost exclusively in osteoblasts, which is believed to adopt a type III (N-out/C-out) topology. Mutations in IFITM5 cause OI type V, but the characteristics of the mutant protein and the mechanism involved are still unknown. The purpose of the current study was to re-assess the topology, localization, and biochemical properties of BRIL and compare it to the OI type V...

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Identifiers

PMID: 24715519
DOI: 10.1002/jbmr.2243

Genes

IFITM5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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