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Article

Neurofibromatosis type 1 alternative splicing is a key regulator of Ras signaling in neurons.

Molecular and cellular biology - 1 Jun 2014

Hinman Melissa N, Sharma Alok, Luo Guangbin, Lou Hua

Abstract excerpt

Neurofibromatosis type I (Nf1) is a GTPase-activating protein (GAP) that inactivates the oncoprotein Ras and plays important roles in nervous system development and learning. Alternative exon 23a falls within the Nf1 GAP domain coding sequence and is tightly regulated in favor of skipping in neurons; however, its biological function is not fully understood. Here we generated mouse embryonic stem (ES) cells with a...

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Identifiers

PMID: 24710274
DOI: 10.1128/MCB.00019-14
PMCID: PMC4054297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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