Article
High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhão state, Northeast Brazil.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2014
Barros Lena Maria Fonseca, Gomes-Gouvêa Michele Soares, Kramvis Anna, Mendes-Corrêa Maria Cássia Jacintho, dos Santos Alexsandro, Souza Letícia Alana Barros, Santos Max Diego Cruz, Carrilho Flair José, de Jesus Domicini Arnaldo, Pinho João Renato Rebello, de Souza Paiva Ferreira Adalgisa
Abstract excerpt
In this study, we determined the prevalence of HBV subgenotypes in Maranhão state, located in northeastern Brazil, where the population is heterogeneous, with a high proportion of African descendants. HBV was detected in 119 of 133 (89.5%) chronic hepatitis B patients, including 103 (86.5%) who were HBeAg-negative. Using phylogenetic analysis of the S/Polymerase region of HBV DNA, subgenotype A1 was found to be...
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