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Article

Uniparental Trisomy of a Mutated HRAS Proto-Oncogene in Embryonal Rhabdomyosarcoma of a Patient With Costello Syndrome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2015

Menke Jan, Pauli Silke, Sigler Matthias, Kühnle Ingrid, Shoukier Moneef, Zoll Barbara, Ganster Christina, Salinas-Riester Gabriela, Schaefer Inga-Marie

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Topics

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Share to Abdominal Neoplasms
Share to Chemotherapy, Adjuvant
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Costello Syndrome

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Share to Proto-Oncogene Mas

Share to Rhabdomyosarcoma, Embryonal

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Source

Identifiers

PMID: 24637993
DOI: 10.1200/JCO.2013.49.6539

Genes

HRAS

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uniparental Trisomy of a Mutated HRAS Proto-Oncogene in Embryonal Rhabdomyosarcoma of a Patient With Costello Syndrome.PMID 24637993Read ↗

HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.Semantic proximity Read ↗

Germline mutations in HRAS proto-oncogene cause Costello syndrome.Semantic proximity Read ↗

Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome.Semantic proximity Read ↗

Male-to-male transmission of Costello syndrome: G12S HRAS germline mutation inherited from a father with somatic mosaicism.Semantic proximity Read ↗

Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma.Semantic proximity Read ↗

De novo HRAS gene mutation associated with Costello syndrome identified by non-invasive cell-free fetal DNA screening.Semantic proximity Read ↗

[A pathogenic variation of HRAS gene causing Costello syndrome: a Ras/MAPK pathway syndrome].Semantic proximity Read ↗

[Mutations in H-Ras proto-oncogen in Costello syndrome].Semantic proximity Read ↗

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.Semantic proximity Read ↗

The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer.Semantic proximity Read ↗

Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.Semantic proximity Read ↗

Phenotypic and Genetic Characteristics of Five Korean Patients with Costello Syndrome.Semantic proximity Read ↗

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