Article
Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014
Wilde Sandra, Timpson Adrian, Kirsanow Karola, Kaiser Elke, Kayser Manfred, Unterländer Martina, Hollfelder Nina, Potekhina Inna D, Schier Wolfram, Thomas Mark G, Burger Joachim
Abstract excerpt
Pigmentation is a polygenic trait encompassing some of the most visible phenotypic variation observed in humans. Here we present direct estimates of selection acting on functional alleles in three key genes known to be involved in human pigmentation pathways--HERC2, SLC45A2, and TYR--using allele frequency estimates from Eneolithic, Bronze Age, and modern Eastern European samples and forward simulations....
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