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Article

Origin and loss of nested LRRTM/α-catenin genes during vertebrate evolution.

PloS one - 1 Jan 2014

Uvarov Pavel, Kajander Tommi, Airaksinen Matti S

Abstract excerpt

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) form in mammals a family of four postsynaptic adhesion proteins, which have been shown to bind neurexins and heparan sulphate proteoglycan (HSPG) glypican on the presynaptic side. Mutations in the genes encoding LRRTMs and neurexins are implicated in human cognitive disorders such as schizophrenia and autism. Our analysis shows that in most jawed...

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PMID: 24587117
DOI: 10.1371/journal.pone.0089910
PMCID: PMC3933685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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