Article
CFTR genotype and clinical outcomes of adult patients carried as cystic fibrosis disease.
Gene - 1 May 2014
Bonadia Luciana Cardoso, de Lima Marson Fernando Augusto, Ribeiro Jose Dirceu, Paschoal Ilma Aparecida, Pereira Monica Corso, Ribeiro Antonio Fernando, Bertuzzo Carmen Silvia
Abstract excerpt
BACKGROUND: There are nearly 2000 cystic fibrosis transmembrane regulator (CFTR) mutations that cause cystic fibrosis (CF). These mutations are classified into six classes; on the one hand, the first three classes cause severe disease involvement in early childhood, on the other hand, the Class IV, V and VI mutations cause minor severe disease in the same age. Nowadays, with therapeutic advances in CF management...
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