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Article

VPS35 Parkinson's disease phenotype resembles the sporadic disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2014

Struhal Walter, Presslauer Stefan, Spielberger Sabine, Zimprich Alexander, Auff Eduard, Bruecke Thomas, Poewe Werner, Ransmayr Gerhard

Abstract excerpt

Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patients compared to sporadic PD patients. However, we were unable to identify a specific clinical maker of VPS35 patients,...

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Source

Identifiers

PMID: 24557499
DOI: 10.1007/s00702-014-1179-1

Genes

VPS35

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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VPS35 Parkinson's disease phenotype resembles the sporadic disease.PMID 24557499Read ↗

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A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.Semantic proximity Read ↗

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.Semantic proximity Read ↗

An assessment of the frequency of mutations in the GBA and VPS35 genes in Hungarian patients with sporadic Parkinson's disease.Semantic proximity Read ↗

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