Article
Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.
Current biology : CB - 17 Feb 2014
Domyan Eric T, Guernsey Michael W, Kronenberg Zev, Krishnan Shreyas, Boissy Raymond E, Vickrey Anna I, Rodgers Clifford, Cassidy Pamela, Leachman Sancy A, Fondon John W, Yandell Mark, Shapiro Michael D
Abstract excerpt
Understanding the molecular basis of phenotypic diversity is a critical challenge in biology, yet we know little about the mechanistic effects of different mutations and epistatic relationships among loci that contribute to complex traits. Pigmentation genetics offers a powerful model for identifying mutations underlying diversity and for determining how additional complexity emerges from interactions among loci....
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