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Article

Design and application of bispecific splice-switching oligonucleotides.

Nucleic acid therapeutics - 1 Feb 2014

Bestas Burcu, McClorey Graham, Tedebark Ulf, Moreno Pedro M D, Roberts Thomas C, Hammond Suzan M, Smith C I Edvard, Wood Matthew J A, Andaloussi Samir El

Abstract excerpt

Targeting of pre-mRNA by short splice-switching oligonucleotides (SSOs) is increasingly being used as a therapeutic modality, one rationale being to disrupt splicing so as to remove exons containing premature termination codons, or to restore the translation reading frame around out-of-frame deletion mutations. The aim of this study was to investigate the effect of chemically linking individual SSOs so as to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24506779
DOI: 10.1089/nat.2013.0462

Genes

DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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