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Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection

28 Jun 2013

Abstract excerpt

BACKGROUND: Antimicrobial use is thought to suppress the intestinal microbiota, thereby impairing colonization resistance and allowing Clostridium difficile to infect the gut. Additional risk factors such as proton-pump inhibitors may also alter the intestinal microbiota and predispose patients to Clostridium difficile infection (CDI). This comparative metagenomic study investigates the relationship between...

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PMID: 24450844
DOI: 10.1186/2049-2618-1-18

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