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Article

Development of allele-specific gene-silencing siRNAs for TGFBI Arg124Cys in lattice corneal dystrophy type I.

Investigative ophthalmology & visual science - 18 Feb 2014

Courtney David G, Atkinson Sarah D, Moore Johnny E, Maurizi Eleonora, Serafini Chiara, Pellegrini Graziella, Black Graeme C, Manson Forbes D, Yam Gary H F, Macewen Caroline J, Allen Edwin H A, McLean W H Irwin, Moore C B Tara

Abstract excerpt

PURPOSE: This study aimed to investigate the potency and specificity of short-interfering RNA (siRNA) treatment for TGFBI-Arg124Cys lattice corneal dystrophy type I (LCDI) using exogenous expression constructs in model systems and endogenous gene targeting in an ex vivo model using corneal epithe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

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Source

Identifiers

PMID: 24425855
DOI: 10.1167/iovs.13-13279

Genes

TGFBI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24425855-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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