Article
A genome scan conducted in a multigenerational pedigree with convergent strabismus supports a complex genetic determinism.
PloS one - 1 Jan 2013
Georges Anouk, Cambisano Nadine, Ahariz Naïma, Karim Latifa, Georges Michel
Abstract excerpt
A genome-wide linkage scan was conducted in a Northern-European multigenerational pedigree with nine of 40 related members affected with concomitant strabismus. Twenty-seven members of the pedigree including all affected individuals were genotyped using a SNP array interrogating > 300,000 common SNPs. We conducted parametric and non-parametric linkage analyses assuming segregation of an autosomal dominant...
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