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Article

Differences in behavior and activity associated with a poly(a) expansion in the dopamine transporter in Belgian Malinois.

PloS one - 1 Jan 2013

Lit Lisa, Belanger Janelle M, Boehm Debby, Lybarger Nathan, Oberbauer Anita M

Abstract excerpt

In Belgian Malinois dogs, a 38-base pair variable number tandem repeat in the dopamine transporter gene (SLC6A3) is associated with behavior changes in Malinois. By additional sequencing in SLC6A3, we identified an intronic 12-nucleotide poly(A) insertion ("PolyA(22)") before the terminal exon that was associated with seizure, "glazing over" behaviors, and episodic biting behaviors in a sample of 138 Malinois. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24376613
DOI: 10.1371/journal.pone.0082948
PMCID: PMC3871558

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