Weekly oral alendronate in mevalonate kinase deficiency

Abstract excerpt

BACKGROUND: Mevalonate kinase deficiency (MKD) is caused by mutations in the MVK gene, encoding the second enzyme of mevalonate pathway, which results in subsequent shortage of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and gastrointestinal symptoms, sometimes induced by vaccinations. METHODS: For a history of early-onset corticosteroid-induced reduction of bone mineral...

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