Article
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes.
American journal of human genetics - 5 Dec 2013
Lohmueller Kirk E, Sparsø Thomas, Li Qibin, Andersson Ehm, Korneliussen Thorfinn, Albrechtsen Anders, Banasik Karina, Grarup Niels, Hallgrimsdottir Ingileif, Kiil Kristoffer, Kilpeläinen Tuomas O, Krarup Nikolaj T, Pers Tune H, Sanchez Gaston, Hu Youna, Degiorgio Michael, Jørgensen Torben, Sandbæk Annelli, Lauritzen Torsten, Brunak Søren, Kristiansen Karsten, Li Yingrui, Hansen Torben, Wang Jun, Nielsen Rasmus, Pedersen Oluf
Abstract excerpt
It has been hypothesized that, in aggregate, rare variants in coding regions of genes explain a substantial fraction of the heritability of common diseases. We sequenced the exomes of 1,000 Danish cases with common forms of type 2 diabetes (including body mass index > 27.5 kg/m(2) and hypertension) and 1,000 healthy controls to an average depth of 56×. Our simulations suggest that our study had the statistical...
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