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Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2014

Orlova Valeria V, Drabsch Yvette, Freund Christian, Petrus-Reurer Sandra, van den Hil Francijna E, Muenthaisong Suchitra, Dijke Peter Ten, Mummery Christine L

Abstract excerpt

OBJECTIVE: Endothelial cells (ECs), pericytes, and vascular smooth muscle cells (vSMCs) are essential for vascular development, and their dysfunction causes multiple cardiovascular diseases. Primary vascular cells for research are, however, difficult to obtain. Human-induced pluripotent stem cells (hiPSCs) derived from somatic tissue are a renewable source of ECs and vSMCs; however, their use as disease models...

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PMID: 24158517
DOI: 10.1161/ATVBAHA.113.302598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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