Article
Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.
PLoS genetics - 1 Jan 2013
Belele Christiane L, Sidorenko Lyudmila, Stam Maike, Bader Rechien, Arteaga-Vazquez Mario A, Chandler Vicki L
Abstract excerpt
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles. Paramutation at the b1 locus involves RNA-mediated transcriptional silencing and requires specific tandem repeats that generate siRNAs. This study addressed three important questions: 1) are the tandem repeats sufficient for...
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