Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.

doi:10.1371/journal.pgen.1003773

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Article

Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.

PLoS genetics - 1 Jan 2013

Belele Christiane L, Sidorenko Lyudmila, Stam Maike, Bader Rechien, Arteaga-Vazquez Mario A, Chandler Vicki L

Abstract excerpt

Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles. Paramutation at the b1 locus involves RNA-mediated transcriptional silencing and requires specific tandem repeats that generate siRNAs. This study addressed three important questions: 1) are the tandem repeats sufficient for...

Topics

Alleles
Base Sequence
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Plant
Gene Silencing
Mutation
Plants, Genetically Modified
RNA
RNA, Small Interfering
Tandem Repeat Sequences
Transcription, Genetic
Zea mays

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Identifiers

PMID: 24146624
DOI: 10.1371/journal.pgen.1003773
PMCID: PMC3798267

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