Article
Use of first-generation HCV protease inhibitors in patients coinfected by HIV and HCV genotype 1.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2014
Salmon-Ceron Dominique, Arvieux Cédric, Bourlière Marc, Cacoub Patrice, Halfon Philippe, Lacombe Karine, Pageaux Georges-Philippe, Pialoux Gilles, Piroth Lionel, Poizot-Martin Isabelle, Rosenthal Eric, Pol Stanislas
Abstract excerpt
BACKGROUND: In HCV genotype 1-infected patients with HIV co-infection, tritherapy [HCV protease inhibitors (PIs) plus peg-interferon and ribavirin] has been shown to have an increased rate of sustained virological response. However, complex drug-to-drug interactions and tolerability issues remain a concern. METHODS: Under the auspices of four French scientific societies of medicine, a committee was charged of...
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