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Article

Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis.

The Plant journal : for cell and molecular biology - 1 Dec 2013

Wu Wenjuan, Zhu Ying, Ma Zhaoxue, Sun Yi, Quan Quan, Li Peng, Hu Pengzhan, Shi Tieliu, Lo Clive, Chu Ivan K, Huang Jirong

Abstract excerpt

Chloroplast development in plants is regulated by a series of coordinated biological processes. In this work, a genetic suppressor screen for the leaf variegation phenotype of the thylakoid formation 1 (thf1) mutant combined with a proteomic assay was employed to elucidate this complicated network. We identified a mutation in ClpR4, named clpR4-3, which leads to leaf virescence and also rescues the var2...

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PMID: 24124904
DOI: 10.1111/tpj.12344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis.PMID 24124904Read ↗

Chloroplast SRP54 and FtsH protease coordinate thylakoid membrane-associated proteostasis in Arabidopsis.Semantic proximity Read ↗

Genetic interactions reveal that specific defects of chloroplast translation are associated with the suppression of var2-mediated leaf variegation.Semantic proximity Read ↗

Mutations in SUPPRESSOR OF VARIEGATION1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis.Semantic proximity Read ↗

The balance between protein synthesis and degradation in chloroplasts determines leaf variegation in Arabidopsis yellow variegated mutants.Semantic proximity Read ↗

A var2 leaf variegation suppressor locus, SUPPRESSOR OF VARIEGATION3, encodes a putative chloroplast translation elongation factor that is important for chloroplast development in the cold.Semantic proximity Read ↗

Mutations in ClpC2/Hsp100 suppress the requirement for FtsH in thylakoid membrane biogenesis.Semantic proximity Read ↗

Down-regulation of specific plastid ribosomal proteins suppresses thf1 leaf variegation, implying a role of THF1 in plastid gene expression.Semantic proximity Read ↗

Simultaneous defects in chloroplast development and division cause leaf variegation in Arabidopsis.Semantic proximity Read ↗

The PUB4 E3 Ubiquitin Ligase Is Responsible for the Variegated Phenotype Observed upon Alteration of Chloroplast Protein Homeostasis in Arabidopsis Cotyledons.Semantic proximity Read ↗

VAR2/AtFtsH2 and EVR2/BCM1/CBD1 synergistically regulate the accumulation of PSII reaction centre D1 protein during de-etiolation in Arabidopsis.Semantic proximity Read ↗

The chloroplast metalloproteases VAR2 and EGY1 act synergistically to regulate chloroplast development in Arabidopsis.Semantic proximity Read ↗

Mutations in the Arabidopsis VAR2 locus cause leaf variegation due to the loss of a chloroplast FtsH protease.Semantic proximity Read ↗

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