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DNA Damage Responses and Oxidative Stress in Dyskeratosis Congenita

4 Oct 2013

Abstract excerpt

Dyskeratosis congenita (DC) is an inherited multisystem disorder of premature aging, cancer predisposition, and bone marrow failure caused by selective exhaustion of highly proliferative cell pools. DC patients also have a poor tolerance to chemo/radiotherapy and bone marrow transplantation. Although critically shortened telomeres and defective telomere maintenance contribute to DC pathology, other mechanisms...

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Share to DNA Repair Mechanisms
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PMID: 24124565
DOI: 10.1371/journal.pone.0076473

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