Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb Ischemia

2 Oct 2013

Abstract excerpt

In this study, we target the hypoxia inducible factor-1 alpha (HIF-1-alpha) pathway by short hairpin RNA interference therapy targeting prolyl hydroxylase-2 (shPHD2). We use the minicircle (MC) vector technology as an alternative for conventional nonviral plasmid (PL) vectors in order to improve neovascularization after unilateral hindlimb ischemia in a murine model. Gene expression and transfection efficiency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Aortic aneurysm repair treatments
Share to Peripheral Artery Disease Management

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24090375
DOI: 10.1089/hum.2013.110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb IschemiaPMID 24090375Read ↗

Double VEGF/HGF Gene Therapy in Critical Limb Ischemia Complicated by Diabetes MellitusSemantic proximity Read ↗

Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemiaSemantic proximity Read ↗

Genetically modified human placenta-derived mesenchymal stem cells with FGF-2 and PDGF-BB enhance neovascularization in a model of hindlimb ischemiaSemantic proximity Read ↗

Preclinical Evaluation of Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb IschemiaSemantic proximity Read ↗

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemiaSemantic proximity Read ↗

pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcers: A Phase II, Double-Blind, Randomized Placebo-Controlled TrialSemantic proximity Read ↗

Advancements in Gene-Based Therapeutic Angiogenesis for Chronic Limb-Threatening IschemiaSemantic proximity Read ↗

Human Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hind Limb Ischemia by Promoting Angiogenesis in MiceSemantic proximity Read ↗

Hypoxia-inducible plasmid expressing both miSHP-1 and HO-1 for the treatment of ischemic diseaseSemantic proximity Read ↗

Hepatocyte Growth Factor Gene Therapy for Ischemic DiseasesSemantic proximity Read ↗

Gene therapy for peripheral arterial diseaseSemantic proximity Read ↗

Gene Transfer of Prolyl Hydroxylase Domain 2 Inhibits Hypoxia-inducible Angiogenesis in a Model of Choroidal NeovascularizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.