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Article

Impact of Helicobacter pylori biofilm formation on clarithromycin susceptibility and generation of resistance mutations.

PloS one - 1 Jan 2013

Yonezawa Hideo, Osaki Takako, Hanawa Tomoko, Kurata Satoshi, Ochiai Kuniyasu, Kamiya Shigeru

Abstract excerpt

The human gastric pathogen Helicobacter pylori forms biofilms in vitro and in vivo. The purpose of this study was to evaluate the effects of H. pylori biofilm formation in vitro on clarithromycin (CLR) susceptibility. CLR susceptibility of H. pylori intermediate (2-day) and mature (3-day) biofilms on glass coverslips was determined at concentrations from 0.03 to 0.5 µg/ml. H. pylori biofilm biomass was increased...

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Share to Anti-Bacterial Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Bacterial

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Share to RNA, Ribosomal, 23S

Source

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Identifiers

PMID: 24039906
DOI: 10.1371/journal.pone.0073301
PMCID: PMC3765302

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